Orsini is a surname of Italian origin, originally derived from Latin ursinus ("bearlike") and originating as an epithet or sobriquet describing the name-bearer's purported strength. Notable people with the surname include the following:
- Alessandro Orsini (sociologist) Italian sociologist
 - Angel Orsini, American wrestler and bodybuilder
 - Felice Orsini (1819–1858), Italian revolutionary who attempted to assassinate Napoléon III
 - Francesca Orsini, Italian scholar of South Asian literature
 - Giambattista Orsini (d. 1503), Italian Catholic Cardinal instrumental in the 1492 Papal Conclave
 - Marina Orsini (born 1967), Canadian actress
 - Nicolás Orsini (born 1994), Argentine footballer
 - Richard Orsini, 13th-century ruler in Italy and the Balkans
 - Umberto Orsini (born 1934), Italian stage, television, and film actor
 - Valentino Orsini (1927–2001), Italian film director
 
- Orsini family, Italian noble family, including:
- Alessandro Orsini (cardinal) (1592–1626), cardinal
 - Clarice Orsini (1453–1488), wife of Lorenzo de' Medici, Lady Of Florence, mother of Pope Leo X
 - Fulvio Orsini (1529–1600), Italian historian
 - Giordano Orsini (died 1438) (died 1438), 15th-century Italian cardinal
 - Giordano Orsini (died 1173) (died 1173), Catholic prelate
 - Giorgio Orsini (1410–1475), architect and sculptor
 - Pope Nicholas III, born Giovanni Gaetano Orsini
 - Giovanni Gaetano Orsini (cardinal) (c.1285–1335), nephew of Pope Nicholas III
 - John II Orsini (died 1335), known as the Despot of Epirus
 - Latino Orsini (1411–1477), Catholic cardinal
 - Latino Malabranca Orsini (d. 1294), Catholic prelate
 - Matteo Orsini (d. 1340), Catholic prelate
 - Napoleone Orsini (1420–1480), condottiero and papal commander
 - Paolo Orsini (1369-1416), condottiero
 - Paolo Orsini (1450-1503), condottiero
 - Paolo Giordano I Orsini (1541–1585), first duke of Bracciano
 - Paolo Giordano II Orsini (1591–1656), nobleman
 - Pope Benedict XIII, born Pietro Francisco Orsini
 - Rinaldo Orsini (d. 1450), Lord of Piombino
 - Virginio Orsini (1434–1497), Lord of Bracciano
 
 
See also
- All pages with titles containing Orsini
 
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