Zosimus, Zosimos, Zosima or Zosimas may refer to:
People
- Rufus and Zosimus (died 107), Christian saints
 - Zosimus (martyr) (died 110), Christian martyr who was executed in Umbria, Italy
 - Zosimos of Panopolis, also known as Zosimus Alchemista, 3rd-century alchemist
 - Zosimus the Hermit, 3rd-century Christian ascetic
 - Zosimus, bishop of Naples, c. 356 – c. 362
 - Zosimas of Palestine (c. 460 – c. 560), Eastern Orthodox saint
 - Zosimas of Solovki (died 1478), Russian Orthodox saint, founder of Solovetsky Monastery
 - Pope Zosimus (died 418), born in Mesoraca, Calabria, who reigned from 417 to his death in 418
 - Zosimus (historian), 5th-century Byzantine historian
 - Zosimos of Samosata, mosaicist at Zeugma
 - Zosimus, 5th-century hermit who discovered Mary of Egypt in the desert
 - Zosimus the Epigrammist in Anthologia Graeca
 - John Zosimus (Ioane-Zosime), 10th-century Georgian monk and hymnist
 - Zosimus, Metropolitan of Moscow (died 1494), Metropolitan of Moscow and Russia from 1490, author of the Third Rome conception
 
- Zosimo Paredes (born 1948), Filipino politician
 
- Zosima, character in the novel The Brothers Karamazov by Fyodor Dostoyevsky
 
Biology
- Zosimus (crab), a genus of crabs in the family Xanthidae
 - Zosima (plant), a genus of plants in the family Apiaceae
 
See also
- Story of Zosimus, Old Testament apocrypha
 - Zozimus (c. 1794–1846), Irish street rhymer
 
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