Yusupov (Russian: Юсу́пов) or Yusupova (feminine; Юсу́пова) is a Chechen, Tatar and Uzbek surname, which is common in the countries of the former Soviet Union. It may refer to:
- House of Yusupov, royal Russian family, of Tatar descent
- Felix Yusupov (1887–1967), Count Sumarokov-Elston, Russian aristocrat and one of the participants in the murder of Grigori Rasputin
- Irina Yusupova (1915–1993), Russian Princess and daughter of Count Felix Yusupov
- Zinaida Nikolaevna Yusupova (1861–1939), Russian Princess and mother of Count Felix Yusupov
- Aliya Yusupova (b. 1984), Kazakhstan gymnast
- Artur Yusupov (b. 1960), chess grandmaster
- Benjamin Yusupov (born 1962), Israeli composer
- Ibroyim Yusupov (1929–2008), Karakalpak poet, playwright, translator and teacher
- Iosef Yusupov (born 1955), American set designer born in Uzbekistan
- Ismail Yusupov (1913–2005), Kazakhstan politician
- Iraida Yusupova (b. 1962), Turkmenistan composer
- Lidia Yusupova (b. 1961), human rights activist
- Tuti Yusupova (1880–2015), Uzbekistani longevity claimant
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