Uncoupling or uncouple may refer to:
- Uncoupling (neuropsychopharmacology), changes in neurochemical binding sites as a consequence of drug tolerance.
 
- An uncoupling protein in cell biology.
 - An uncoupling agent in cell biology.
 
- Uncoupling (or decoupling) rail vehicles.
 
See also
- Decoupling (disambiguation)
 - Coupling (disambiguation)
 - Coupler (disambiguation)
 - Couple (disambiguation)
 - Uncoupled, a Netflix romantic comedy series starring Neil Patrick Harris
 
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