UIS may refer to:
- Uis, a village in Erongo Region, Namibia
 - Underwater Inspection System, a component of the Underwater Port Security System developed for the United States Coast Guard
 - Universal Interactive Studios (now Vivendi Games)
 - University of Illinois Springfield, a public four-year university in the United States
 - Universidad Industrial de Santander, Colombia
 - University of Stavanger, Norway
 - Union Internationale de Spéléologie, an international umbrella organization for caving and speleology
 - Unisys Corporation NYSE stock symbol
 - UIs, plural abbreviation of user interface
 - Uisai language, ISO 639-3 code
 - Umpire Information System, made by QuesTec and used for providing feedback and evaluation of Major League umpires
 - UNESCO Institute for Statistics
 
See also
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