Soulsby may refer to:
- Ben Soulsby, lumbermill owner and founder of Soulsbyville, California, USA
 - Heidi Soulsby, British politician from Guernsey
 - Henry Soulsby, builder of the 1926 Soulsby Service Station on U.S. Route 66 in Mount Olive, Illinois.
 - James Soulsby (1897–1980), English footballer
 - Lawson Soulsby, Baron Soulsby of Swaffham Prior (1926–2017), British microbiologist and parasitologist
 - Sir Peter Soulsby (born 1948), British politician, Mayor of Leicester
 - Sir William Soulsby (1851–1937), English barrister, Private Secretary to the Lord Mayor of London
 
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