Simeone is a surname. Notable people with the surname include:
- Carmelo Simeone (1934–2014), Argentine former football player
- Diego Simeone (born 1970), Argentine football manager and former player
- Gianluca Simeone (born 1998), Argentine football player
- Giovanni Simeone (born 1995), Argentine football player
- Giuliano Simeone (born 2002), Argentine football player
- Lee Jason Simeone (born 1980), English musician
- Osvaldo Simeone, American engineer
See also
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