S&D often refers to the Progressive Alliance of Socialists and Democrats. It may also refer to:
- Search and destroy, refers to a military strategy that became a notorious component of the Vietnam War
 - Silver & Deming, a type of reduced-shank drill bits
 - Somerset & Dorset Joint Railway, was an English railway line
 - Speech and Debate
 - Spybot – Search & Destroy, a popular spyware and adware removal program compatible with Microsoft Windows 95 and later
 - Supply and demand, an economic model of price determination in a market
 
See also
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