López is a surname of Spanish origin. López or Lopez may also refer to:
Fictional characters:
- Lopez, a character in Red vs. Blue; see List of characters in Red vs. Blue
 - López (portrayed by Pedro Armendáriz Jr.), a character and antagonist in the 1999 film Herod's Law
 
In geography:
- Lopez, Cauca, town and municipality in the Cauca Department, Colombia
 - Lopez, Quezon, a municipality in the Philippines
 - Lopez Jaena, Misamis Occidental, a municipality in the Philippines
 - López, Chihuahua, one of the municipalities of Chihuahua, Mexico
 - Lopez Island, San Juan Islands, Washington, USA
 - Lopez River in Monroe County, Florida
 - López (Santa Fe), town and municipality in Santa Fe province, Argentina
 
Other uses:
- United States v. Lopez, a United States Supreme Court case
 - Lopez (TV series), a television series starring George Lopez
 
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