Isaac Davis may refer to:
- Isaac Davis (soldier) (1745–1775), Revolutionary War Minuteman captain
 - Isaac Davis (advisor) (1758–1810), Welsh advisor to Kamehameha I
 - Isaac Davis (lawyer) (1799–1883), lawyer active in Worcester, Massachusetts
 - Isaac Davis (American football) (born 1972), American football player
 - Ike Davis (born 1987), American baseball first baseman
 - Ike Davis (shortstop) (1895–1984), American baseball shortstop
 - Isaac Mortimer Davis, the protagonist of Woody Allen's 1979 film Manhattan
 
See also
- Isaac Davis Trail, historic trail in Massachusetts, United States
 - Isaac Davis House, historic house in Massachusetts, United States
 - David Isaacs (disambiguation)
 
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