Fort Wayne, Indiana is the second-largest city in the U.S. state of Indiana.
Fort Wayne may also refer to:
- Fort Wayne (fort), the fort which gave its name to the city of Fort Wayne
 - Fort Wayne (Detroit), a fort in Michigan
 - Fort Wayne (Indian Territory), two early frontier army forts in Indian Territory (now Oklahoma)
 - USS Fort Wayne, a United States Navy transport during World War I
 - Purdue Fort Wayne Mastodons, the athletic program of Purdue University Fort Wayne
 
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