Fort Lyon may refer to:
- Fort Lyon, Colorado, a U.S. Army fort used until 1897
 - Fort Lyon, Colorado, an unincorporated town
 - Fort Lyon (Virginia), part of the defenses of Washington DC during the American Civil War
 - Fort Lyon (Maine), a coast defense fort active 1905-1946
 - Fort Lyon, former name of Fort Wingate, near Gallup, New Mexico
 - Camp Lyon (California), sometimes called Fort Lyon, established in 1862 and later abandoned
 
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