Blassingame is a surname. Notable people with the surname include:
- Jerel Blassingame (born 1981), American professional basketball player
 - John Wesley Blassingame (1940–2000), American historian and writer
 - Lurton Blassingame (1904–1988), American literary agent
 - Tia Blassingame (born 1971), American artist
 - William Blassingame (born 1836), American politician
 - Wyatt Rainey Blassingame (1909–1985), American author
 
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